The purpose of this study was to investigate the effects of 8 weeks resistance

training (RT) on α -1A protein of pre-synaptic P-Q-type Calcium Channels in

FHL and soleus muscles of rats. 16 male wistar rats provided from razi institute,

randomly divided to 2 groups (Control-Sham; n=8 and Resistance Training; n=

8). Training group conducted 8 weeks (5 session/week) resistance program on

special 1 meter height ladder (divided by 26 stairs) with loading 30% body

weight (suspended from the tail) in the first week and increased to 200% BW in

the last week. Training includes 3 set of 4 reps. with 3 min. rest between sets.

Measuring α -1A protein with Western Blotting and independent T test showed

that the amount of this protein insignificantly increased in FHL muscles of RT

group (FHL: 77.88±10.67 vs. Control: 70.01± 6.28 and soleus: 72.71±19.72 vs.

Control: 72.57 ± 20.20). This insignificant increase in α -1A protein in FHL, can

shows an responsiveness of pre-synaptic P-Q-type Calcium Channels of

muscles following resistance training for improving Ach release from presynaptic

terminal, noted in NMJ adaptations . In conclusion, we can express

that probably resistance training can be a main factor for α -1A protein improving

in muscles and this case should be study in future investigations with high

volume and intensities training