دوره 21، شماره 26 - ( 10-1402 )                   جلد 21 شماره 26 صفحات 88-77 | برگشت به فهرست نسخه ها

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Shahabpoor E, Delavari M A. Investigating The Effect Of Endurance Training as a Therapeutic Method On Muscle Cachexia and Cardiovascular Consequences caused by Breast Cancer. RSMT 2023; 21 (26) :77-88
URL: http://jsmt.khu.ac.ir/article-1-606-fa.html
شهاب‌پور الهام، دلاوری محمد امین. بررسی تأثیر تمرین استقامتی به عنوان یک روش کمک‌درمان بر کاشکسی‌عضلانی و عواقب قلبی عروقی در موش‌های مبتلا به سرطان پستان. پژوهش در طب ورزشی و فناوری. 1402; 21 (26) :77-88

URL: http://jsmt.khu.ac.ir/article-1-606-fa.html


دانشگاه هرمزگان ، e.shahabpour@hormozgan.ac.ir
چکیده:   (1486 مشاهده)
سندروم کاشکسی و خطر مواجهه با بیماری‌های قلبی عروقی شیوع بالایی در بیماران سرطانی دارد؛ بنابراین، پژوهش حاضر با هدف بررسی تأثیر تمرین استقامتی به عنوان یک روش کمک‌درمان بر کاشکسی ­عضلانی و عواقب قلبی عروقی ناشی از سرطان­ پستان انجام شد. 20 سر موش بالب­سی (شش تا هشت هفته­ایی با میانگین توده بدنی 17-18 گرم) پس از القای سرطان پستان و گذشت 2 هفته، تست توان هوازی بیشینه را اجرا کردند و به‌طور تصادفی به دو گروه تومور-کنترل و تومور-تمرین تقسیم شدند. گروه تومور-تمرین، پروتکل تمرین استقامتی را به مدت 6 هفته، 5 روز در هفته با افزایش تدریجی شدت 12 متر به 20 متر در دقیقه و مدت زمان 25 دقیقه تا 55 دقیقه انجام و 24 ساعت پس از آخرین جلسه تمرین تست توان هوازی بیشینه به عمل آمد. 48 ساعت پس از آخرین جلسه تمرین موش­ها قربانی شدند. وزن بدن، وزن غذای‌مصرفی، وزن قلب، وزن طحال، وزن عضله دوقلو و نعلی، شاخص توده قلبی و نسبت وزن عضله نعلی به وزن بدن و نسبت وزن عضله دوقلو به وزن بدن در دو گروه تومور-کنترل و تومور-تمرین اندازه‌گیری شد. جهت تجزیه و تحلیل داده­ها از آزمون آماری تی­ مستقل در سطح معناداری 05/0P< استفاده شد. نتایج تحقیق حاضر افزایش معنادار در وزن قلب (005/0P= وزن طحال (029/0P=)، عضله دوقلو (009/0P=) و عضله نعلی (022/0P= در گروه تومور-تمرین نسبت به گروه تومور-کنترل را نشان داد. همچنین افزایش معنادار شاخص توده قلبی (016/0P=) و نسبت وزن عضله دوقلو به وزن بدن (005/0P=) و نسبت عضله نعلی به وزن بدن (021/0P=) در گروه تومور-تمرین نسبت به گروه تومور-کنترل مشاهده شد. درنتیجه، به نظر می­رسد تمرین استقامتی می­تواند به عنوان یک روش کمک درمانی و استراتژی بالقوه برای بهبود سلامت دستگاه عضلات اسکلتی، قلب و عروق و کاهش روند کاشکسی عضلانی ناشی از سرطان پستان مورد توجه قرار گیرد.



 
متن کامل [PDF 1891 kb]   (219 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: فیزیولوژی ورزشی
دریافت: 1402/5/17 | پذیرش: 1402/8/23 | انتشار: 1402/10/10

فهرست منابع
1. Refrences:
2. Kontomanolis EN, Kalagasidou S, Pouliliou S, Anthoulaki X, Georgiou N, Papamanolis V, Fasoulakis ZN. The notch pathway in breast cancer progression. The Scientific World Journal. 2018 Oct;2018. [DOI:10.1155/2018/2415489]
3. Mo H, Jazieh KA, Brinzevich D, Abraham J. A review of treatment-induced pulmonary toxicity in breast cancer. Clinical Breast Cancer. 2022 Jan 1;22(1):1-9. [DOI:10.1016/j.clbc.2021.05.014]
4. Perez IE, Taveras Alam S, Hernandez GA, Sancassani R. Cancer therapy-related cardiac dysfunction: an overview for the clinician. Clinical Medicine Insights: Cardiology. 2019 Jul;13:1179546819866445. [DOI:10.1177/1179546819866445]
5. Bonsignore A, Warburton D. The mechanisms responsible for exercise intolerance in early-stage breast cancer: What role does chemotherapy play?. Hong Kong Physiotherapy Journal. 2013 Jun 1;31(1):2-11. [DOI:10.1016/j.hkpj.2013.03.002]
6. DeSantis C, Jemal A, Ward E, Thun MJ. Temporal trends in breast cancer mortality by state and race. Cancer Causes & Control. 2008 Jun;19:537-45. [DOI:10.1007/s10552-008-9113-1]
7. Tsitkanou S, Murach KA, Washington TA, Greene NP. Exercise counteracts the deleterious effects of cancer cachexia. Cancers. 2022 May 19;14(10):2512. [DOI:10.3390/cancers14102512]
8. Khori V, Shalamzari SA, Isanejad A, Alizadeh AM, Alizadeh S, Khodayari S, Khodayari H, Shahbazi S, Zahedi A, Sohanaki H, Khaniki M. Effects of exercise training together with tamoxifen in reducing mammary tumor burden in mice: possible underlying pathway of miR-21. European journal of pharmacology. 2015 Oct 15;765:179-87 [DOI:10.1016/j.ejphar.2015.08.031]
9. Jones LW, Courneya KS, Mackey JR, Muss HB, Pituskin EN, Scott JM, Hornsby WE, Coan AD, Herndon JE, Douglas PS, Haykowsky M. Cardiopulmonary function and age-related decline across the breast cancer survivorship continuum. Journal of clinical oncology. 2012 Jul 7;30(20):2530. [DOI:10.1200/JCO.2011.39.9014]
10. Niels T, Tomanek A, Freitag N, Schumann M. Can exercise counteract cancer cachexia? A systematic literature review and meta-analysis. Integrative cancer therapies. 2020 Sep;19:1534735420940414. [DOI:10.1177/1534735420940414]
11. Helmark IC, Mikkelsen UR, Børglum J, Rothe A, Petersen MC, Andersen O, Langberg H, Kjaer M. Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial. Arthritis research & therapy. 2010 Aug;12:1-1. [DOI:10.1186/ar3064]
12. Lim C, Nunes EA, Currier BS, Mcleod JC, Thomas AC, Phillips SM. An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise-Induced Human Skeletal Muscle Hypertrophy. Medicine and science in sports and exercise. 2022 Sep;54(9):1546. [DOI:10.1249/MSS.0000000000002929]
13. Figueira AC, Pereira A, Leitão L, Ferreira R, Oliveira PA, Duarte JA. Effects of Moderate Exercise Training on Cancer-Induced Muscle Wasting. InHealthcare 2023 Sep 29 (Vol. 11, No. 19, p. 2652). [DOI:10.3390/healthcare11192652]
14. H. Zieff G, W. Wagoner C, Paterson C, Pagan Lassalle P, T. Lee J. Cardiovascular consequences of skeletal muscle impairments in breast cancer. Sports. 2020 May 31;8(6):80. [DOI:10.3390/sports8060080]
15. Shalamzari SA, Agha-Alinejad H, Alizadeh S, Shahbazi S, Khatib ZK, Kazemi A, Saei MA, Minayi N. The effect of exercise training on the level of tissue IL-6 and vascular endothelial growth factor in breast cancer bearing mice. Iranian journal of basic medical sciences. 2014 Apr;17(4):231.
16. Manzari Tavakoli Z, Amani Shalamzari S, Kazemi A. Effects of 6 weeks' Endurance Training on Oncostatin-M in Muscle and Tumor Tissues in mice with Breast Cancer. Iranian Journal of Breast Diseases. 2017 Mar 10;9(4):50-9.URL:
17. Høydal MA, Wisløff U, Kemi OJ, Ellingsen Ø. Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training. European Journal of Preventive Cardiology. 2007 Dec 1;14(6):753-60. [DOI:10.1097/HJR.0b013e3281eacef1]
18. Aveseh M, Nikooie R, Aminaie M. Exercise‐induced changes in tumour LDH‐B and MCT1 expression are modulated by oestrogen‐related receptor alpha in breast cancer‐bearing BALB/c mice. The Journal of physiology. 2015 Jun 15;593(12):2635-48. [DOI:10.1113/JP270463]
19. Betof AS, Dewhirst MW, Jones LW. Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. Brain, behavior, and immunity. 2013 Mar 15;30:S75-87.. [DOI:10.1016/j.bbi.2012.05.001]
20. Shadravan M, Amani-Shalamzari S, Sarikhani A. Effects of 6 weeks of aerobic training on the level of serum and tumour tissues ghrelin in mice with breast cancer. Journal of Practical Studies of Biosciences in Sport. 2020 Mar 20;8(15):22-33.
21. Pedersen BK, Saltin B. Exercise as medicine-evidence for prescribing exercise as therapy in 26 different chronic diseases. Scandinavian journal of medicine & science in sports. 2015 Dec;25:1-72. [DOI:10.1111/sms.12581]
22. Beaudry RI, Howden EJ, Foulkes S, Bigaran A, Claus P, Haykowsky MJ, Gerche AL. Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy. Physiological reports. 2019 Jan;7(1):e13971.. [DOI:10.14814/phy2.13971]
23. VanderVeen BN, Fix DK, Counts BR, Carson JA. The effect of wheel exercise on functional indices of cachexia in tumor-bearing mice. Medicine and science in sports and exercise. 2020 Nov;52(11):2320. [DOI:10.1249/MSS.0000000000002393]
24. Jones LW, Haykowsky MJ, Swartz JJ, Douglas PS, Mackey JR. Early breast cancer therapy and cardiovascular injury. Journal of the American College of Cardiology. 2007 Oct 9;50(15):1435-41. [DOI:10.1016/j.jacc.2007.06.037]
25. Park NJ, Chang Y, Bender C, Conley Y, Chlebowski RT, Van Londen GJ, Foraker R, Wassertheil-Smoller S, Stefanick ML, Kuller LH. Cardiovascular disease and mortality after breast cancer in postmenopausal women: results from the Women's Health Initiative. PloS one. 2017 Sep 21;12(9):e0184174.. [DOI:10.1371/journal.pone.0184174]
26. Alves de Lima Jr E, Teixeira AA, Biondo LA, Diniz TA, Silveira LS, Coletti D, Busquets Rius S, Rosa Neto JC. Exercise reduces the resumption of tumor growth and proteolytic pathways in the skeletal muscle of mice following chemotherapy. Cancers. 2020 Nov 20;12(11):3466. [DOI:10.3390/cancers12113466]
27. Gerritsen JK, Vincent AJ. Exercise improves quality of life in patients with cancer: a systematic review and meta-analysis of randomised controlled trials. British Journal of Sports Medicine. 2015 Dec 30. [DOI:10.1136/bjsports-2015-094787]
28. Winters-Stone KM, Bennett JA, Nail L, Schwartz A. Strength, physical activity, and age predict fatigue in older breast cancer survivors. InOncology nursing forum 2008 Sep 1 (Vol. 35, No. 5). [DOI:10.1188/08.ONF.815-821]
29. Beaudry RI, Kirkham AA, Thompson RB, Grenier JG, Mackey JR, Haykowsky MJ. Exercise Intolerance in Anthracycline‐Treated Breast Cancer Survivors: The Role of Skeletal Muscle Bioenergetics, Oxygenation, and Composition. The Oncologist. 2020 May 1;25(5):e852-60 . [DOI:10.1634/theoncologist.2019-0777]
30. Atella V, Piano Mortari A, Kopinska J, Belotti F, Lapi F, Cricelli C, Fontana L. Trends in age‐related disease burden and healthcare utilization. Aging cell. 2019 Feb;18(1):e12861. [DOI:10.1111/acel.12861]
31. Butt Z, Rosenbloom SK, Abernethy AP, Beaumont JL, Paul D, Hampton D, Jacobsen PB, Syrjala KL, Von Roenn JH, Cella D. Fatigue is the most important symptom for advanced cancer patients who have had chemotherapy. Journal of the National Comprehensive Cancer Network. 2008 May 1;6(5):448-55. [DOI:10.6004/jnccn.2008.0036]
32. Refrences:
33. Kontomanolis EN, Kalagasidou S, Pouliliou S, Anthoulaki X, Georgiou N, Papamanolis V, Fasoulakis ZN. The notch pathway in breast cancer progression. The Scientific World Journal. 2018 Oct;2018. [DOI:10.1155/2018/2415489]
34. Mo H, Jazieh KA, Brinzevich D, Abraham J. A review of treatment-induced pulmonary toxicity in breast cancer. Clinical Breast Cancer. 2022 Jan 1;22(1):1-9. [DOI:10.1016/j.clbc.2021.05.014]
35. Perez IE, Taveras Alam S, Hernandez GA, Sancassani R. Cancer therapy-related cardiac dysfunction: an overview for the clinician. Clinical Medicine Insights: Cardiology. 2019 Jul;13:1179546819866445. [DOI:10.1177/1179546819866445]
36. Bonsignore A, Warburton D. The mechanisms responsible for exercise intolerance in early-stage breast cancer: What role does chemotherapy play?. Hong Kong Physiotherapy Journal. 2013 Jun 1;31(1):2-11. [DOI:10.1016/j.hkpj.2013.03.002]
37. DeSantis C, Jemal A, Ward E, Thun MJ. Temporal trends in breast cancer mortality by state and race. Cancer Causes & Control. 2008 Jun;19:537-45. [DOI:10.1007/s10552-008-9113-1]
38. Tsitkanou S, Murach KA, Washington TA, Greene NP. Exercise counteracts the deleterious effects of cancer cachexia. Cancers. 2022 May 19;14(10):2512. [DOI:10.3390/cancers14102512]
39. Khori V, Shalamzari SA, Isanejad A, Alizadeh AM, Alizadeh S, Khodayari S, Khodayari H, Shahbazi S, Zahedi A, Sohanaki H, Khaniki M. Effects of exercise training together with tamoxifen in reducing mammary tumor burden in mice: possible underlying pathway of miR-21. European journal of pharmacology. 2015 Oct 15;765:179-87 [DOI:10.1016/j.ejphar.2015.08.031]
40. Jones LW, Courneya KS, Mackey JR, Muss HB, Pituskin EN, Scott JM, Hornsby WE, Coan AD, Herndon JE, Douglas PS, Haykowsky M. Cardiopulmonary function and age-related decline across the breast cancer survivorship continuum. Journal of clinical oncology. 2012 Jul 7;30(20):2530. [DOI:10.1200/JCO.2011.39.9014]
41. Niels T, Tomanek A, Freitag N, Schumann M. Can exercise counteract cancer cachexia? A systematic literature review and meta-analysis. Integrative cancer therapies. 2020 Sep;19:1534735420940414. [DOI:10.1177/1534735420940414]
42. Helmark IC, Mikkelsen UR, Børglum J, Rothe A, Petersen MC, Andersen O, Langberg H, Kjaer M. Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial. Arthritis research & therapy. 2010 Aug;12:1-1. [DOI:10.1186/ar3064]
43. Lim C, Nunes EA, Currier BS, Mcleod JC, Thomas AC, Phillips SM. An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise-Induced Human Skeletal Muscle Hypertrophy. Medicine and science in sports and exercise. 2022 Sep;54(9):1546. [DOI:10.1249/MSS.0000000000002929]
44. Figueira AC, Pereira A, Leitão L, Ferreira R, Oliveira PA, Duarte JA. Effects of Moderate Exercise Training on Cancer-Induced Muscle Wasting. InHealthcare 2023 Sep 29 (Vol. 11, No. 19, p. 2652). [DOI:10.3390/healthcare11192652]
45. H. Zieff G, W. Wagoner C, Paterson C, Pagan Lassalle P, T. Lee J. Cardiovascular consequences of skeletal muscle impairments in breast cancer. Sports. 2020 May 31;8(6):80. [DOI:10.3390/sports8060080]
46. Shalamzari SA, Agha-Alinejad H, Alizadeh S, Shahbazi S, Khatib ZK, Kazemi A, Saei MA, Minayi N. The effect of exercise training on the level of tissue IL-6 and vascular endothelial growth factor in breast cancer bearing mice. Iranian journal of basic medical sciences. 2014 Apr;17(4):231.
47. Manzari Tavakoli Z, Amani Shalamzari S, Kazemi A. Effects of 6 weeks' Endurance Training on Oncostatin-M in Muscle and Tumor Tissues in mice with Breast Cancer. Iranian Journal of Breast Diseases. 2017 Mar 10;9(4):50-9.URL:
48. Høydal MA, Wisløff U, Kemi OJ, Ellingsen Ø. Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training. European Journal of Preventive Cardiology. 2007 Dec 1;14(6):753-60. [DOI:10.1097/HJR.0b013e3281eacef1]
49. Aveseh M, Nikooie R, Aminaie M. Exercise‐induced changes in tumour LDH‐B and MCT1 expression are modulated by oestrogen‐related receptor alpha in breast cancer‐bearing BALB/c mice. The Journal of physiology. 2015 Jun 15;593(12):2635-48. [DOI:10.1113/JP270463]
50. Betof AS, Dewhirst MW, Jones LW. Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. Brain, behavior, and immunity. 2013 Mar 15;30:S75-87.. [DOI:10.1016/j.bbi.2012.05.001]
51. Shadravan M, Amani-Shalamzari S, Sarikhani A. Effects of 6 weeks of aerobic training on the level of serum and tumour tissues ghrelin in mice with breast cancer. Journal of Practical Studies of Biosciences in Sport. 2020 Mar 20;8(15):22-33.
52. Pedersen BK, Saltin B. Exercise as medicine-evidence for prescribing exercise as therapy in 26 different chronic diseases. Scandinavian journal of medicine & science in sports. 2015 Dec;25:1-72. [DOI:10.1111/sms.12581]
53. Beaudry RI, Howden EJ, Foulkes S, Bigaran A, Claus P, Haykowsky MJ, Gerche AL. Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy. Physiological reports. 2019 Jan;7(1):e13971.. [DOI:10.14814/phy2.13971]
54. VanderVeen BN, Fix DK, Counts BR, Carson JA. The effect of wheel exercise on functional indices of cachexia in tumor-bearing mice. Medicine and science in sports and exercise. 2020 Nov;52(11):2320. [DOI:10.1249/MSS.0000000000002393]
55. Jones LW, Haykowsky MJ, Swartz JJ, Douglas PS, Mackey JR. Early breast cancer therapy and cardiovascular injury. Journal of the American College of Cardiology. 2007 Oct 9;50(15):1435-41. [DOI:10.1016/j.jacc.2007.06.037]
56. Park NJ, Chang Y, Bender C, Conley Y, Chlebowski RT, Van Londen GJ, Foraker R, Wassertheil-Smoller S, Stefanick ML, Kuller LH. Cardiovascular disease and mortality after breast cancer in postmenopausal women: results from the Women's Health Initiative. PloS one. 2017 Sep 21;12(9):e0184174.. [DOI:10.1371/journal.pone.0184174]
57. Alves de Lima Jr E, Teixeira AA, Biondo LA, Diniz TA, Silveira LS, Coletti D, Busquets Rius S, Rosa Neto JC. Exercise reduces the resumption of tumor growth and proteolytic pathways in the skeletal muscle of mice following chemotherapy. Cancers. 2020 Nov 20;12(11):3466. [DOI:10.3390/cancers12113466]
58. Gerritsen JK, Vincent AJ. Exercise improves quality of life in patients with cancer: a systematic review and meta-analysis of randomised controlled trials. British Journal of Sports Medicine. 2015 Dec 30. [DOI:10.1136/bjsports-2015-094787]
59. Winters-Stone KM, Bennett JA, Nail L, Schwartz A. Strength, physical activity, and age predict fatigue in older breast cancer survivors. InOncology nursing forum 2008 Sep 1 (Vol. 35, No. 5). [DOI:10.1188/08.ONF.815-821]
60. Beaudry RI, Kirkham AA, Thompson RB, Grenier JG, Mackey JR, Haykowsky MJ. Exercise Intolerance in Anthracycline‐Treated Breast Cancer Survivors: The Role of Skeletal Muscle Bioenergetics, Oxygenation, and Composition. The Oncologist. 2020 May 1;25(5):e852-60 . [DOI:10.1634/theoncologist.2019-0777]
61. Atella V, Piano Mortari A, Kopinska J, Belotti F, Lapi F, Cricelli C, Fontana L. Trends in age‐related disease burden and healthcare utilization. Aging cell. 2019 Feb;18(1):e12861. [DOI:10.1111/acel.12861]
62. Butt Z, Rosenbloom SK, Abernethy AP, Beaumont JL, Paul D, Hampton D, Jacobsen PB, Syrjala KL, Von Roenn JH, Cella D. Fatigue is the most important symptom for advanced cancer patients who have had chemotherapy. Journal of the National Comprehensive Cancer Network. 2008 May 1;6(5):448-55. [DOI:10.6004/jnccn.2008.0036]

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