Effect Of Physical Activity In Enriched Movement Environment On The Expression Of Aryl Hydrocarbon Receptor And Ornithine Decarboxylase-1 In The Cerebellum Of Mouse Model Of Multiple Sclerosis

Emadi, Samira; SHahrbanian, SHahnaz; Kordi, Mohammadreza; Molanouri shamsi, Mahdieh

Volume 23, Issue 29 (7-2025) RSMT 2025, 23(29): 20-36 | Back to browse issues page

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Emadi S, SHahrbanian S, Kordi M, Molanouri shamsi M. Effect Of Physical Activity In Enriched Movement Environment On The Expression Of Aryl Hydrocarbon Receptor And Ornithine Decarboxylase-1 In The Cerebellum Of Mouse Model Of Multiple Sclerosis. RSMT 2025; 23 (29) :20-36
URL: http://jsmt.khu.ac.ir/article-1-600-en.html

Effect Of Physical Activity In Enriched Movement Environment On The Expression Of Aryl Hydrocarbon Receptor And Ornithine Decarboxylase-1 In The Cerebellum Of Mouse Model Of Multiple Sclerosis

Samira Emadi

, SHahnaz SHahrbanian

, Mohammadreza Kordi

, Mahdieh Molanouri shamsi

Associate Professor of Exercise Physiology, Department of Sports Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran. , sh.shahrbanian@modares.ac.ir

Abstract: (4113 Views)

Introduction:Disruption of the homeostasis of immune regulatory mediators Aryl hydrocarbon receptor (AhR) and Ornithine decarboxylase-1(ODC-1) is involved in the pathogenesis of multiple sclerosis (MS). Physical activities play a role in controlling and improving the symptoms of MS. This study aimed to investigate the effect of 4 weeks of physical activity in enriched movement environment on the gene expression of AhR and ODC-1 in the cerebellum tissue of an MS mice model.
Method: This experimental study was conducted on 30 female C57BL/6 mice (age: 8 weeks and average weight: 18 ± 2). Mice were divided into 3 groups of 10 including 1) healthy control, 2) Induction of experimental autoimmune encephalomyelitis (EAE) and 3) EAE + physical activity in enriched movement environment for 4 weeks. Clinical score were recorded daily from induction until 28 days. The gene expression of AhR and ODC-1 in the cerebellum was measured by RT-PCR method. Statistical analysis of the data was performed using one-way analysis of variance.
Results: Activity in the enriched movement environment significantly decreased the gene expression of AhR compared to the EAE group (P=0/02) and also decreased the gene expression of ODC-1, but it was not statistically significant (P=0/28). Also, the clinical score improved significantly after activity in the enriched movement environment (P= 0/001).
Conclusion: In general, it seems that lifestyle change and activity in enriched movement environment lead to the down regulation of the gene expression of AhR and ODC-1 in the cerebellum and improved the clinical score of animals with MS.

Keywords: Aryl Hydrocarbon Receptor, Ornithine Decarboxylase-1, Experimental Autoimmune Encephalomyelitis, Physical Activity In Enriched Movement Environment, Cerebellum

Full-Text [PDF 2462 kb] (36 Downloads)

Type of Study: Research | Subject: sport physiology
Received: 2024/06/8 | Accepted: 2025/01/8 | Published: 2025/07/1

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