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University of Mazandaran , UMZ.kheradmand@gmail.com
Abstract:   (740 Views)
The prevalence of obesity in women, especially after menopause, is higher compared to men. Menopause is associated with a decrease in estrogen and leads to dysfunction of mitochondria. The purpose of this study is to investigate the effect of intense aerobic exercise training on the copy number of mitochondrial genome (mtDNA) and mitochondrial transcription factor A (Tfam) in ovariectomized rats fed by high-fat diet. 40 rats were divided into 5 groups: 1) normal diet, 2) normal diet + ovariectomy, 3) high-fat diet, 4) high-fat diet + ovariectomy, and 5) high-fat diet + ovariectomy + intense exercise. The exercise group performed aerobic exercise training (80-85% of maximum oxygen consumption) for 8 weeks/5 sessions in every week. 48 hours after the last training session, visceral adipose tissue samples were taken to evaluate the copy number of mtDNA and Tfam gene expression. Ovariectomy and high-fat diet did not lead to a significant change in Tfam gene expression, but caused a significant decrease in the copy number of mtDNA compared to the control group. Intense exercise caused a significant increase in Tfam gene expression compared to the control group and Tfam gene expression and the copy number of mtDNA compared to the high-fat diet + ovariectomy group. Intense aerobic exercise training improves mtDNA copy number in ovariectomized rats fed by high-fat diet.
Type of Study: Research | Subject: sport physiology
Received: 2023/06/6 | Accepted: 2023/08/23

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