دوره 21، شماره 26 - ( 10-1402 )
جلد 21 شماره 26 صفحات 17-1 |
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Soltani M, Barzegari A, Naghibi S, Dashty khavidaki M H. The Effect of Aerobic Exercise and Quercetin Supplementation on Myostatin and Follistatin Levels in the Heart Tissue of Rats with Type 2 Diabetes. RSMT 2023; 21 (26) :1-17
URL: http://jsmt.khu.ac.ir/article-1-528-fa.html
URL: http://jsmt.khu.ac.ir/article-1-528-fa.html
سلطانی محسن، برزگری علی، نقیبی سعید، دشتی خویدکی محمد حسن. تأثیر تمرین هوازی و مکمل کوئرستین بر سطح مایواستاتین و فول‌استاتین در بافت قلب رت‌های مبتلا به دیابت نوع دو. پژوهش در طب ورزشی و فناوری. 1402; 21 (26) :1-17
دانشگاه پیام نور ، ali_barzegari@pnu.ac.ir
چکیده: (2850 مشاهده)
این مطالعه با هدف تأثیر تمرین و مکمل کوئرستین بر سطح مایواستاتین و فول‌استاتین در بافت قلب رت‌های دیابتی صورت گرفت. بدین منظور تعداد 50 سر موش نر ویستار 10 هفتهای با میانگین وزنی 33±237 گرم به‌طور تصادفی در پنج گروه 10 تایی شامل: کنترل سالم، دیابت، دیابت+مکمل، دیابت+تمرین و دیابت+مکمل+تمرین قرار گرفتند. پروتکل تمرینی شامل پنج جلسه در هفته به مدت هشت هفته روی نوار گردان بدون شیب ویژه جوندگان به مدت 60 دقیقه و با سرعت 25 متر در دقیقه در هر جلسه دویدند و گروه‌های مکمل نیز به صورت گاواژ روزانه به مقدار 50 میلی‌گرم به ازای کیلوگرم وزن بدن کوئرستین را دریافت کردند. تغییرات مایواستاتین و فول‌استاتین بافت قلب رتها با استفاده از روش الایزا مورد بررسی قرار گرفت. نتایج نشان داد که اختلاف سطوح مایواستاتین در میان گروه‌ها معنی‌دار است (001/0P=). سطوح مایواستاتین بین گروه تمرین+مکمل+دیابت با دیابت کاهش معنی‌داری داشت (002/0P=). میان گروه‌های مکمل+دیابت و تمرین+دیابت نیز تفاوت معنی‌داری وجود داشت (009/0P=). همچنین نتایج نشان داد که اختلاف سطوح فول‌استاتین در میان گروه‌ها معنی‌دار است (001/0P=). نتایج نشان داد سطوح فول‌استاتین بافت قلب میان گروه‌های دیابت، تمرین+دیابت، مکمل+دیابت و تمرین+مکمل+دیابت با گروه کنترل افزایش معنی‌داری داشت (به ترتیب: 005/0P=؛ 001/0P=؛ 001/0P=؛ 001/0P=). به نظر می‌رسد تمرین هوازی با شدت متوسط و مصرف مکمل کوئرستین تأثیر مثبت و مفیدی بر سطح میوستاتین و فول‌استاتین دارد.
نوع مطالعه: پژوهشي |
موضوع مقاله:
فیزیولوژی ورزشی
دریافت: 1401/1/25 | پذیرش: 1402/3/8 | انتشار: 1402/10/10
دریافت: 1401/1/25 | پذیرش: 1402/3/8 | انتشار: 1402/10/10
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