Volume 21, Issue 26 (12-2023)                   RSMT 2023, 21(26): 129-140 | Back to browse issues page

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fazeli V, Motamedi P, Rajabi H, Khaledi N. The Effect Of Combined Training On Aortic Atherosclerosis And FGF23 In Male Rats With Chronic Renal Failure. RSMT 2023; 21 (26) :129-140
URL: http://jsmt.khu.ac.ir/article-1-369-en.html
Kharazmi Of University , pezhman.motamedi@khu.ac.ir
Abstract:   (4349 Views)
Objective: The aim of the present study was to investigate the effect of combined exercise on aortic atherosclerosis and FGF23 in male rats with chronic renal failure. Methods: In this study, 20 male Wistar rats (mean weight 10 ± 250  g) were induced by NX5 / 6 method for chronic renal failure. After 2 weeks of recovery, they were randomly divided into two groups of control (n= 10) and combined training (n= 10) and performed a combined training protocol for 8 weeks. The combined training protocol consisted of two resistance training exercises on a ladder with 2 sets and 6 repetitions with percentages of body weight and aerobic exercise included 30 minutes of low-intensity treadmill activity. Results: The results showed that combined exercise reduced aortic atherosclerosis and decreased plaques, and FGF23 decreased significantly (p = 0.001). Parathoromon hormone also significantly decreased (p = 0.041) and calcium and phosphorus significantly decreased (p = 0.004 and p = 0.005, respectively). Conclusion: Overall, the results showed that combined training could decrease FGF23, parathoromon hormone, calcium and phosphor on aortic atherosclerosis and cardiovascular disease indices in chronic renal failure patients.
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Type of Study: Research |
Received: 2023/04/6 | Accepted: 2023/11/25 | Published: 2023/12/31

References
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4. Bansal, S., Prasad, A., Linas, S. (2018) 'Right Heart Failure-Unrecognized Cause of Cardiorenal Syndrome', Journal of the American Society of Nephrology., 29(7), :1795-1798. [DOI:10.1681/ASN.2018020224]
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6. Lekawanvijit, S. (2018) 'Cardiotoxicity of Uremic Toxins: A Driver of Cardiorenal Syndrome', Toxins., 10(9), :352. [DOI:10.3390/toxins10090352]
7. Tsuruya, Kazuhiko, Eriguchi, Masahiro, Yamada, Shunsuke, Hirakata, Hideki, Kitazono, Takanari (2015) 'Cardiorenal Syndrome in End-Stage Kidney Disease', Blood Purification., 40(4), :337-343. [DOI:10.1159/000441583]
8. Tsuruya, K., Eriguchi, M. (2015) 'Cardiorenal syndrome in chronic kidney disease', Current Opinion in Nephrology and Hypertension., 24(2), :154-162. [DOI:10.1097/MNH.0000000000000099]
9. Li, Dong-Jie, Fu, Hui, Zhao, Ting, Ni, Min, Shen, Fu-Ming. (2016) 'Exercise-stimulated FGF23 promotes exercise performance via controlling the excess reactive oxygen species production and enhancing mitochondrial function in skeletal muscle', Metabolism., 65(5), :747-756. [DOI:10.1016/j.metabol.2016.02.009]
10. Anderson, Lindsey, Oldridge, Neil, Thompson, David R., Zwisler, Ann-Dorthe, Rees, Karen, Martin, Nicole, Taylor, Rod S. (2016) 'Exercise-Based Cardiac Rehabilitation for Coronary Heart Disease', Journal of the American College of Cardiology., 67(1), :1-12. [DOI:10.1016/j.jacc.2015.10.044]
11. Moraes, Milton Rocha, Rosa, Thiago Santos, Souza, Michel Kendy, Neves, Rodrigo Vanerson Passos, Bacurau, Reury Frank Pereira, Passos, Clévia Santos, Cenedeze, Marcos Antônio, Passos, Michelle Tiveron, Machado, Flávia Gomes, Pacheco-Silva, Filho, Alvaro, Câmara, Niels Olsen Saraiva (2018) 'Resistance training downregulates macrophages infiltration in the kidney of 5/6 nephrectomized rats', Life Sciences., 213, :190-197. [DOI:10.1016/j.lfs.2018.10.037]
12. Inder, Jodie D., Carlson, Deborah J., Dieberg, Gudrun, Mcfarlane, James R., Hess, Nicole C.L., Smart, Neil A. (2016) 'Isometric exercise training for blood pressure management: A systematic review and meta-analysis to optimize benefit', Hypertension Research., 39(2), :89-94. [DOI:10.1038/hr.2015.111]
13. Fakhrpour, R., Ebrahim Kh., Ahmadizad, S., Tayebi Khosroshahi, H. (2016). Effects of Combined Training on FGF23 and Some Vascular Calcification Risk Factors in Hemodialysis Patients. Medical Journal of Tabriz University of Medical Science. 38(3):84-91. (Persian).
14. Okabe, Taka Aki, Kishimoto, Chiharu, Murayama, Toshinori, Yokode, Masayuki, Kita, Toru (2006) 'Effects of exercise on the development of atherosclerosis in apolipoprotein E-deficient mice', Experimental and Clinical Cardiology., 11(4), :276-279.
15. Coffey, V. G. and Hawley, J. A. (2017) 'Concurrent exercise training: do opposites distract?', The Journal of Physiology., 595(9), :2883-2896. [DOI:10.1113/JP272270]
16. Pechter, Ü. (2003) 'Beneficial effects of water-based exercise in patients with chronic kidney disease', International Journal of Rehabilitation Research, 26(2), 153-156. [DOI:10.1097/00004356-200306000-00013]
17. Wang, Jianlu, Wang, Lan, Yang, Hongjun, You, Yun, Xu, Haiyu, Gong, Leilei, Yin, Xiaojie, Wang, Wandan, Gao, Shuangrong, Cheng, Long, Liang, Rixin, Liao, Fulong (2015) 'Prevention of atherosclerosis by Yindan Xinnaotong capsule combined with swimming in rats', BMC Complementary and Alternative Medicine., 15(1). :12-19. [DOI:10.1186/s12906-015-0622-7]
18. Hotton, Emily J, Renwick, Sophie, Barnard, Katie, Lenguerrand, Erik, Wade, Julia, Draycott, Tim, Crofts, Joanna F, Blencowe, Natalie S (2019) 'Exploring standardisation, monitoring and training of medical devices in assisted vaginal birth studies: protocol for a systematic review', BMJ Open., 9(4), :84-93. [DOI:10.1136/bmjopen-2018-028300]
19. Aengevaeren, Vincent L., Mosterd, Arend, Braber, Thijs L., Prakken, Niek H.J., Doevendans, Pieter A., Grobbee, Diederick E., Thompson, Paul D., Eijsvogels, Thijs M.H., Velthuis, Birgitta K. (2017) 'Relationship Between Lifelong Exercise Volume and Coronary Atherosclerosis in Athletes', Circulation., 136(2), :138-148. [DOI:10.1161/CIRCULATIONAHA.117.027834]
20. Emrich, I.E., Dederer, J., Kircher, A., Klemis, V., Lennartz, C.S., Untersteller, K., Wagenpfeil, S., Fliser, D., Wolf, M., Heine, G.H. (2019) 'Does a rise in plasma erythropoietin after high-altitude exposure affect FGF23 in healthy volunteers on normal or low phosphorus diet?', Nutrition, Metabolism and Cardiovascular Diseases., 121(6), :120-129. [DOI:10.1016/j.numecd.2019.09.002]
21. Keshavarzi, Z, Daryanoosh, F, Kooshki Jahromi, M, Mohammadi, M (2017) 'The Effect of 12 Weeks of Aerobic Exercise on Plasma Levels of Fibroblast Growth Factor 23, Angiotensin Converting Enzyme and Left Ventricular Hypertrophy in Hypertensive Elderly Women', Journal of Shahid Sadoughi University of Medical Sciences and Health Services., 25(3), :222-229. (Persian).
22. Price, Kym Joanne, Gordon, Brett Ashley, Bird, Stephen Richard, Benson, Amanda Clare (2016) 'A review of guidelines for cardiac rehabilitation exercise programmes: Is there an international consensus?', European Journal of Preventive Cardiology., 23(16), :1715-1733. [DOI:10.1177/2047487316657669]
23. Kohrt, Wendy M, Wherry, Sarah J, Wolfe, Pamela, Sherk, Vanessa D, Wellington, Toby Swanson, Christine M, Weaver, Connie M, Boxer, Rebecca S (2018) 'Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses', Journal of Bone and Mineral Research., 33(7), :1326-1334. [DOI:10.1002/jbmr.3428]
24. BARRY, DANIEL W., HANSEN, KENT C., VAN PELT, RACHAEL E., WITTEN, MICHAEL, WOLFE, PAMELA, KOHRT, WENDY M. (2011) 'Acute Calcium Ingestion Attenuates Exercise-Induced Disruption of Calcium Homeostasis', Medicine & Science in Sports & Exercise., 43(4), :617-623. [DOI:10.1249/MSS.0b013e3181f79fa8]
25. Van Raalte, Judy L., Morrey, Ruth Brennan, Cornelius, Allen E., Brewer, Britton W. (2015) 'Self-Talk of Marathon Runners', The Sport Psychologist., 29(3), :258-260. [DOI:10.1123/tsp.2014-0159]
26. Gardinier, Joseph D., Al-Omaishi, Salam, Morris, Michael D., Kohn, David H. (2016) 'PTH signaling mediates perilacunar remodeling during exercise', Matrix Biology., 52-54, :162-175. [DOI:10.1016/j.matbio.2016.02.010]
27. Duff, Whitney R.D., Kontulainen, Saija A., Candow, Darren G., Gordon, Julianne J., Mason, Riley S., Taylor-Gjevre, Regina, Nair, Bindu, Szafron, Michael, Baxter-Jones, Adam D.G., Zello, Gordon A., Chilibeck, Philip D. (2016) 'Effects of low-dose ibuprofen supplementation and resistance training on bone and muscle in postmenopausal women: A randomized controlled trial', Bone Reports., 5, :96-103. [DOI:10.1016/j.bonr.2016.04.004]
28. GOHDA, TOMOHITO, SUZUKI, HITOSHI, HIDAKA, TERUO, UEDA, SEIJI, SUZUKI, YUSUKE (2018). 'An Uupdate of Ppathogenesis and Ttreatment in Ppatients with Cchronic Kkidney Ddisease (CKD) and Ccardio-Rrenal Ssyndrome',. Juntendo Medical Journal,. 64(3),:227-234. [DOI:10.14789/jmj.2018.64.JMJ18-LN02]
29. Núñez, Julio, Garcia, Sergio, Núñez, Eduardo, Bonanad, Clara, Bodí, Vicent, Miñana, Gema, Santas, Enrique, Escribano, David, Bayes-Genis, Antonio, Pascual-Figal, Domingo, Chorro, Francisco J, Sanchis, Juan (2017). 'Early serum creatinine changes and outcomes in patients admitted for acute heart failure: the cardio-renal syndrome revisited',. European Heart Journal: Acute Cardiovascular Care,. 6(5),:430-440. [DOI:10.1177/2048872614540094]
30. Ronco, C., Bellasi, A., Di Lullo, L. (2018) 'Cardiorenal Syndrome: An Overview', Advances in Chronic Kidney Disease., 25(5), :382-390. [DOI:10.1053/j.ackd.2018.08.004]
31. Bansal, S., Prasad, A., Linas, S. (2018) 'Right Heart Failure-Unrecognized Cause of Cardiorenal Syndrome', Journal of the American Society of Nephrology., 29(7), :1795-1798. [DOI:10.1681/ASN.2018020224]
32. Sheu, Jiunn-Jye, Ali, Hani E.E., Cheng, Ben-Chung, Chiang, Hsin-Ju, Sung, Pei-Hsun, Chen, Kuan-Hung, Yang, Chih-Chao, Chen, Yen-Ta, Chiang, John Y., Lin, Pao-Yuan, Chua, Sarah, Chai, Han-Tan, Chung, Sheng-Ying, Sun, Cheuk-Kwan, Yip, Hon-Kan (2017) 'Extracorporeal shock wave treatment attenuated left ventricular dysfunction and remodeling in mini-pig with cardiorenal syndrome', Oncotarget., 8(33), :36-45. [DOI:10.18632/oncotarget.18287]
33. Lekawanvijit, S. (2018) 'Cardiotoxicity of Uremic Toxins: A Driver of Cardiorenal Syndrome', Toxins., 10(9), :352. [DOI:10.3390/toxins10090352]
34. Tsuruya, Kazuhiko, Eriguchi, Masahiro, Yamada, Shunsuke, Hirakata, Hideki, Kitazono, Takanari (2015) 'Cardiorenal Syndrome in End-Stage Kidney Disease', Blood Purification., 40(4), :337-343. [DOI:10.1159/000441583]
35. Tsuruya, K., Eriguchi, M. (2015) 'Cardiorenal syndrome in chronic kidney disease', Current Opinion in Nephrology and Hypertension., 24(2), :154-162. [DOI:10.1097/MNH.0000000000000099]
36. Li, Dong-Jie, Fu, Hui, Zhao, Ting, Ni, Min, Shen, Fu-Ming. (2016) 'Exercise-stimulated FGF23 promotes exercise performance via controlling the excess reactive oxygen species production and enhancing mitochondrial function in skeletal muscle', Metabolism., 65(5), :747-756. [DOI:10.1016/j.metabol.2016.02.009]
37. Anderson, Lindsey, Oldridge, Neil, Thompson, David R., Zwisler, Ann-Dorthe, Rees, Karen, Martin, Nicole, Taylor, Rod S. (2016) 'Exercise-Based Cardiac Rehabilitation for Coronary Heart Disease', Journal of the American College of Cardiology., 67(1), :1-12. [DOI:10.1016/j.jacc.2015.10.044]
38. Moraes, Milton Rocha, Rosa, Thiago Santos, Souza, Michel Kendy, Neves, Rodrigo Vanerson Passos, Bacurau, Reury Frank Pereira, Passos, Clévia Santos, Cenedeze, Marcos Antônio, Passos, Michelle Tiveron, Machado, Flávia Gomes, Pacheco-Silva, Filho, Alvaro, Câmara, Niels Olsen Saraiva (2018) 'Resistance training downregulates macrophages infiltration in the kidney of 5/6 nephrectomized rats', Life Sciences., 213, :190-197. [DOI:10.1016/j.lfs.2018.10.037]
39. Inder, Jodie D., Carlson, Deborah J., Dieberg, Gudrun, Mcfarlane, James R., Hess, Nicole C.L., Smart, Neil A. (2016) 'Isometric exercise training for blood pressure management: A systematic review and meta-analysis to optimize benefit', Hypertension Research., 39(2), :89-94. [DOI:10.1038/hr.2015.111]
40. Fakhrpour, R., Ebrahim Kh., Ahmadizad, S., Tayebi Khosroshahi, H. (2016). Effects of Combined Training on FGF23 and Some Vascular Calcification Risk Factors in Hemodialysis Patients. Medical Journal of Tabriz University of Medical Science. 38(3):84-91. (Persian).
41. Okabe, Taka Aki, Kishimoto, Chiharu, Murayama, Toshinori, Yokode, Masayuki, Kita, Toru (2006) 'Effects of exercise on the development of atherosclerosis in apolipoprotein E-deficient mice', Experimental and Clinical Cardiology., 11(4), :276-279.
42. Coffey, V. G. and Hawley, J. A. (2017) 'Concurrent exercise training: do opposites distract?', The Journal of Physiology., 595(9), :2883-2896. [DOI:10.1113/JP272270]
43. Pechter, Ü. (2003) 'Beneficial effects of water-based exercise in patients with chronic kidney disease', International Journal of Rehabilitation Research, 26(2), 153-156. [DOI:10.1097/00004356-200306000-00013]
44. Wang, Jianlu, Wang, Lan, Yang, Hongjun, You, Yun, Xu, Haiyu, Gong, Leilei, Yin, Xiaojie, Wang, Wandan, Gao, Shuangrong, Cheng, Long, Liang, Rixin, Liao, Fulong (2015) 'Prevention of atherosclerosis by Yindan Xinnaotong capsule combined with swimming in rats', BMC Complementary and Alternative Medicine., 15(1). :12-19. [DOI:10.1186/s12906-015-0622-7]
45. Hotton, Emily J, Renwick, Sophie, Barnard, Katie, Lenguerrand, Erik, Wade, Julia, Draycott, Tim, Crofts, Joanna F, Blencowe, Natalie S (2019) 'Exploring standardisation, monitoring and training of medical devices in assisted vaginal birth studies: protocol for a systematic review', BMJ Open., 9(4), :84-93. [DOI:10.1136/bmjopen-2018-028300]
46. Aengevaeren, Vincent L., Mosterd, Arend, Braber, Thijs L., Prakken, Niek H.J., Doevendans, Pieter A., Grobbee, Diederick E., Thompson, Paul D., Eijsvogels, Thijs M.H., Velthuis, Birgitta K. (2017) 'Relationship Between Lifelong Exercise Volume and Coronary Atherosclerosis in Athletes', Circulation., 136(2), :138-148. [DOI:10.1161/CIRCULATIONAHA.117.027834]
47. Emrich, I.E., Dederer, J., Kircher, A., Klemis, V., Lennartz, C.S., Untersteller, K., Wagenpfeil, S., Fliser, D., Wolf, M., Heine, G.H. (2019) 'Does a rise in plasma erythropoietin after high-altitude exposure affect FGF23 in healthy volunteers on normal or low phosphorus diet?', Nutrition, Metabolism and Cardiovascular Diseases., 121(6), :120-129. [DOI:10.1016/j.numecd.2019.09.002]
48. Keshavarzi, Z, Daryanoosh, F, Kooshki Jahromi, M, Mohammadi, M (2017) 'The Effect of 12 Weeks of Aerobic Exercise on Plasma Levels of Fibroblast Growth Factor 23, Angiotensin Converting Enzyme and Left Ventricular Hypertrophy in Hypertensive Elderly Women', Journal of Shahid Sadoughi University of Medical Sciences and Health Services., 25(3), :222-229. (Persian).
49. Price, Kym Joanne, Gordon, Brett Ashley, Bird, Stephen Richard, Benson, Amanda Clare (2016) 'A review of guidelines for cardiac rehabilitation exercise programmes: Is there an international consensus?', European Journal of Preventive Cardiology., 23(16), :1715-1733. [DOI:10.1177/2047487316657669]
50. Kohrt, Wendy M, Wherry, Sarah J, Wolfe, Pamela, Sherk, Vanessa D, Wellington, Toby Swanson, Christine M, Weaver, Connie M, Boxer, Rebecca S (2018) 'Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses', Journal of Bone and Mineral Research., 33(7), :1326-1334. [DOI:10.1002/jbmr.3428]
51. BARRY, DANIEL W., HANSEN, KENT C., VAN PELT, RACHAEL E., WITTEN, MICHAEL, WOLFE, PAMELA, KOHRT, WENDY M. (2011) 'Acute Calcium Ingestion Attenuates Exercise-Induced Disruption of Calcium Homeostasis', Medicine & Science in Sports & Exercise., 43(4), :617-623. [DOI:10.1249/MSS.0b013e3181f79fa8]
52. Van Raalte, Judy L., Morrey, Ruth Brennan, Cornelius, Allen E., Brewer, Britton W. (2015) 'Self-Talk of Marathon Runners', The Sport Psychologist., 29(3), :258-260. [DOI:10.1123/tsp.2014-0159]
53. Gardinier, Joseph D., Al-Omaishi, Salam, Morris, Michael D., Kohn, David H. (2016) 'PTH signaling mediates perilacunar remodeling during exercise', Matrix Biology., 52-54, :162-175. [DOI:10.1016/j.matbio.2016.02.010]
54. Duff, Whitney R.D., Kontulainen, Saija A., Candow, Darren G., Gordon, Julianne J., Mason, Riley S., Taylor-Gjevre, Regina, Nair, Bindu, Szafron, Michael, Baxter-Jones, Adam D.G., Zello, Gordon A., Chilibeck, Philip D. (2016) 'Effects of low-dose ibuprofen supplementation and resistance training on bone and muscle in postmenopausal women: A randomized controlled trial', Bone Reports., 5, :96-103. [DOI:10.1016/j.bonr.2016.04.004]

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